Billions of people are exposed to wood smoke in low- and high-income countries. Wood smoke from wood stoves used for heating and cooking and from forest fires throughout the world due global warming trends cause extensive health effects in susceptible individuals. Therefore, we are focused on understanding extent of local, national and global exposures and the mechanisms by which wood smoke and related pollutants exacerbate COPD and asthma by increasing mucus production and cause decline in lung function.